
Vitamin A and Cancer
Cancer Letters, 1991; 59:25-29 "Anti-Tumor Effects of Vitamin A
Against Shope Carcinoma Cells" Retinol (vitamin A) caused growth retardation as well as changes in
morphology in Shope carcinoma (cultured). The authors came to the conclusion
that vitamin A may be effective against differentiated squamous cell
carcinomas. However, it may not be effective against undifferentiated tumors.
Nutrition and Cancer, "Exposure to Benzopyrene Depletes Tissue Vitamin
A: B-Carotene Prevents Depletion",1991; 208-210. Rats fed benzopyrene had
tissue retinol reduce by 30% in the small intestine and liver. Supplementing
the rats with beta carotene prevented the retinol reduction. It is possible
that taking beta carotene may have a positive impact on environmental
carcinogens.
American Journal of Epidemiology, 1991; 133: 766-75. "Plasma Antioxidant
Vitamins and Subsequent Cancer Mortality in 12-Year Follow-up of the
Prospective Basal Study" Over a two-year period, antioxidant vitamins
(vitamins A, C and E) were measured in 2974 men. During the course of the
study, 204 men died of cancer. In general, mortality was associated with low
levels of vitamin C and carotene.
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